Intrarectal Xyloglucan Administration Reduces Disease Severity in the Dextran Sodium Sulfate Model of Mouse Colitis.
Edward A RossMadelyn H MillerAllison PachecoAlicia R WillenbergJustine T Tigno-AranjuezKaitlyn E CrawfordPublished in: Clinical and experimental gastroenterology (2021)
The striking attenuation of disease severity by intrarectal TXG use warrants future investigations of natural bioadhesives with well-established high safety profiles, and which could potentially be derivatized to include therapeutically active moieties for local drug delivery.