Inhibition of lactate transport by MCT-1 blockade improves chimeric antigen receptor T-cell therapy against B-cell malignancies.

Ernesto LopezRajesh KarattilFrancesco Nannini Gordon Weng-Kit CheungLilian DenzlerFelipe Galvez-CancinoSergio A Quezada Martin A Pule

Published in: Journal for immunotherapy of cancer (2023)

This work highlights the potential of selective targeting of lactate metabolism via MCT-1 in combination with CAR T cells therapies against B-cell malignancies.

Keyphrases

cell therapy
stem cells
mesenchymal stem cells
cancer therapy
bone marrow
climate change
risk assessment