MAZ promotes prostate cancer bone metastasis through transcriptionally activating the KRas-dependent RalGEFs pathway.

Qing YangChuandong LangZhengquan WuYuhu DaiShaofu HeWei GuoShuai HuangHong DuDong RenXinsheng Peng

Published in: Journal of experimental & clinical cancer research : CR (2019)

These results indicate that the MAZ/Kras/ RalGEF signalling axis plays a crucial role in promoting PCa cell bone metastasis, suggesting a potential therapeutic utility of MAZ in bone metastasis of PCa.

Keyphrases

prostate cancer
bone mineral density
soft tissue
bone loss
bone regeneration
radical prostatectomy
single cell
signaling pathway
cell therapy
wild type