Immune Reconstitution Inflammatory Syndrome Due to HIV Treatment as a Potential Trigger: A Case Report with Late-Onset Narcolepsy.
Jiaqin YuTing ShenZongshan LiTian LvLiSan ZhangPublished in: Nature and science of sleep (2024)
Narcolepsy type 1 (NT1) is a unique central sleepiness disorder that affects individuals with excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, and hypnagogic hallucinations. The etiology and pathogenesis of NT1 remains unclear, although some viral infections are thought to be related to NT1. This paper reports an unusual case of late-onset NT1 with human immunodeficiency virus (HIV) infection and antiretroviral therapy for five years. The relationship between HIV infection, immune, Immune reconstitution inflammatory syndrome (IRIS) and NT1 should be further investigated, as excessive daytime sleepiness is more common in HIV-infected patients than in the general population.
Keyphrases
- antiretroviral therapy
- late onset
- human immunodeficiency virus
- hiv infected patients
- sleep quality
- obstructive sleep apnea
- hiv infected
- hiv positive
- hiv aids
- early onset
- positive airway pressure
- sleep apnea
- depressive symptoms
- hepatitis c virus
- oxidative stress
- physical activity
- case report
- mass spectrometry
- hiv testing
- risk assessment