Sex-specific epigenetic signatures of circulating urate and its increase after BCG vaccination.
Zhaoli LiuTania O CrișanCancan QiManoj Kumar GuptaXuan LiuSimone J C F M MoorlagValerie A C M KoekenL Charlotte J de BreeVera P MouritsXu GaoAndrea BaccarelliJoel D SchwartzFrank PesslerCarlos A GuzmánYang LiMihai M NeteaLeo A B JoostenCheng-Jian XuPublished in: Research square (2024)
Our study enhances the understanding of how epigenetic factors contribute to regulating serum urate levels in a sex-specific manner. These insights have significant implications for the diagnosis, prevention, and treatment of various urate-related diseases and highlight the importance of personalized and sex-specific approaches in medicine.