Enhanced Klotho availability protects against cardiac dysfunction induced by uraemic cardiomyopathy by regulating Ca2+ handling.
José Alberto Navarro-GarcíaAngélica RuedaTatiana Romero-GarcíaJennifer Aceves-RipollElena Rodríguez-SánchezLaura González-LafuenteCarlos ZaragozaMaría Fernández-VelascoMakoto Kuro-OLuis M RuilopeLuis M RuilopePublished in: British journal of pharmacology (2020)
Klotho emerges as an attractive therapeutic tool to improve cardiac Ca2+ mishandling observed in uraemic cardiomyopathy. Strategies that improve Klotho availability are good candidates to protect the heart from functional cardiac alterations in renal disease.