Fluorochloridone induces autophagy in TM4 Sertoli cells: involvement of ROS-mediated AKT-mTOR signaling pathway.

Zhijing NiWeiqi SunRui LiMingjun YangFen ZhangXiuli ChangWeihua LiZhijun Zhou

Published in: Reproductive biology and endocrinology : RB&E (2021)

Taken together, our study provided the evidence that FLC promoted autophagy in TM4 Sertoli cells and that this process may involve ROS-mediated AKT/mTOR signaling pathways.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
cell death
endoplasmic reticulum stress
cell proliferation
epithelial mesenchymal transition
oxidative stress
dna damage
reactive oxygen species