IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis.

Isaiah R TurnbullMonty B MazerMark H HoofnagleJohn P KirbyJennifer M LeonardCarlos Mejia-ChewAndrej SpecJane BloodSydney M MilesEric M RansomRobert F PotterJoseph P GautKenneth E RemyRichard S Hotchkiss

Published in: Open forum infectious diseases (2021)

A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.

Keyphrases

case report
soft tissue
intensive care unit
cell wall
candida albicans