HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells.

Priya Pai Guannan Wang Wei Wen Teo Diana Raez-Rodriguez Kathleen L Gabrielson Gyorffy Balazs Bradley M Downs Akanksha Aggarwal Saraswati Sukumar

Published in: Cancer research (2022)

Loss of HOXA5 reduces IκBα stability and increases NF-κB signaling to exacerbate breast cancer aggressiveness, providing new insights into the tumor suppressor functions of HOXA5.

Keyphrases

signaling pathway
long non coding rna
long noncoding rna
lps induced
pi k akt
nuclear factor
oxidative stress
inflammatory response
cell proliferation
immune response