White matter hyperintensities associate with cognitive slowing in patients with systemic lupus erythematosus and neuropsychiatric symptoms.

Rory Caitlin Monahan Francesca IngleseHuub MiddelkoopMark van BuchemThomas Wj HuizingaMargreet KloppenburgItamar RonenGerda M Steup-BeekmanJeroen de Bresser

Published in: RMD open (2021)

We demonstrated that an association between brain and WMH volumes and cognitive function is present in patients with SLE, but differs between (NP)SLE phenotypes. WMHs associated with PS especially in inflammatory NPSLE, which suggests a different, potentially more severe underlying pathophysiological mechanism of cognitive impairment in this phenotype.

Keyphrases

white matter
systemic lupus erythematosus
cognitive impairment
disease activity
multiple sclerosis
oxidative stress
early onset
rheumatoid arthritis
sleep quality
physical activity
depressive symptoms
drug induced