Impact of DNA damage repair defects on response to PSMA radioligand therapy in metastatic castration-resistant prostate cancer.
Bastiaan M PrivéPeter H J SlootbeekBabette I LaarhuisSamhita Pamidimarri NagaMaarten J van der DoelenLudwike W M van KalmthoutBart de KeizerSamer EzziddinClemens KratochwilAlfred MorgensternFrank BruchertseiferMarjolijn J L LigtenbergJ Alfred WitjesInge M van OortMartin GotthardtSandra HeskampMarcel J R JanssenMaarten J van der DoelenJames NagarajahNiven MehraPublished in: Prostate cancer and prostatic diseases (2021)
In this study of a selected cohort, pathogenic DDR aberrations were not associated with exceptional responsiveness to PSMA-RLT. Translational studies in larger prospective cohorts are warranted to associate DDR gene defects with differential responses to PSMA-RLT.