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The plant product quinic acid activates Ca2+ -dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells.

Eija HeikkiläAurelie HermantJonathan ThevenetFlavien BermontSameer S KulkarniJoanna RatajczakJaime Santo-DomingoEl Hadji DioumCarles CantoDenis BarronAndreas WiederkehrUmberto De Marchi
Published in: British journal of pharmacology (2019)
QA modulated intracellular Ca2+ homeostasis, enhancing glucose-stimulated insulin secretion in both INS-1E cells and mouse islets. By increasing mitochondrial Ca2+ , QA activated the coordinated stimulation of oxidative metabolism, mitochondrial ATP synthase-dependent respiration, and therefore insulin secretion. Bioactive agents raising mitochondrial Ca2+ in pancreatic beta-cells could be used to treat diabetes.
Keyphrases
  • induced apoptosis
  • oxidative stress
  • cell cycle arrest
  • type diabetes
  • cardiovascular disease
  • signaling pathway
  • blood pressure
  • metabolic syndrome
  • pi k akt
  • weight loss
  • cell proliferation