The plant product quinic acid activates Ca2+ -dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells.
Eija HeikkiläAurelie HermantJonathan ThevenetFlavien BermontSameer S KulkarniJoanna RatajczakJaime Santo-DomingoEl Hadji DioumCarles CantoDenis BarronAndreas WiederkehrUmberto De MarchiPublished in: British journal of pharmacology (2019)
QA modulated intracellular Ca2+ homeostasis, enhancing glucose-stimulated insulin secretion in both INS-1E cells and mouse islets. By increasing mitochondrial Ca2+ , QA activated the coordinated stimulation of oxidative metabolism, mitochondrial ATP synthase-dependent respiration, and therefore insulin secretion. Bioactive agents raising mitochondrial Ca2+ in pancreatic beta-cells could be used to treat diabetes.