Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment.

Fizzah A ChoudryFrederik O BaggerIain C MacaulaySamantha FarrowFrances BurdenCarly KempsterHarriet McKinneyLars R OlsenNi HuangKate DownesThierry VoetRakesh UppalJohn F MartinAnthony MathurWillem H OuwehandElisa LaurentiSarah A TeichmannMattia Frontini

Published in: Journal of thrombosis and haemostasis : JTH (2021)

Here, we use single-cell sequencing for the first time to characterize the human bone marrow MK transcriptome at different levels of polyploidization and investigate their differentiation from the HSC.

Keyphrases

single cell
endothelial cells
rna seq
bone marrow
gene expression
induced pluripotent stem cells
mesenchymal stem cells
transcription factor
heat stress
heat shock protein