Draft Genome Sequences of 12 Mycolicibacterium smegmatis Strains Resistant to Imidazo[1,2-b][1,2,4,5]Tetrazines.

Aleksey A VatlinKirill V ShurValery N DanilenkoDmitry A Maslov

Published in: Microbiology resource announcements (2019)

Here, we report 12 draft genome sequences of mutant Mycolicibacterium smegmatis strains resistant to imidazo[1,2-b][1,2,4,5]tetrazines, which are antituberculosis drug candidates. We have identified 7 different mutations in the MSMEG_1380 gene, which encodes the AcrR/TetR_N transcriptional repressor, which may activate efflux-mediated resistance.

Keyphrases

genome wide
escherichia coli
gene expression
dna methylation
genetic diversity
adverse drug
oxidative stress
drug induced
electronic health record
heat shock protein