Differential cognitive effects of unilateral left and right subthalamic nucleus deep brain stimulation for Parkinson disease.
Victor A Del BeneRoy C MartinSarah A BrinkerhoffJoseph W OlsonMatthew J NelsonDario Alfredo MarottaChristopher L GonzalezKelly A MillsVidyulata KamathJ Nicole BentleyBarton L GuthrieRobert T KnightHarrison C WalkerPublished in: medRxiv : the preprint server for health sciences (2023)
Directional and ring DBS did not differentially or adversely affect cognition over time. Regarding hemisphere effects, verbal fluency decline was observed in those who received left STN DBS, along with the left and right STN DBS declines in delayed memory. The left STN DBS verbal fluency decrement is consistent with prior bilateral DBS research, likely reflecting disruption of the basal-ganglia-thalamocortical network connecting STN and inferior frontal gyrus. Interestingly, we found an improvement in verbal fluency and response inhibition following right STN DBS. It is possible that unilateral STN DBS, particularly in the right hemisphere, may mitigate cognitive decline.