P7C3 suppresses astrocytic senescence to protect dopaminergic neurons: Implication in the mouse model of Parkinson's disease.

Yajing ChenZengyan ZhuYinghui YanHongyang SunGuanghui WangXiaohuan DuFang LiShuwei YuanWenjing WangMei WangChao Gu

Published in: CNS neuroscience & therapeutics (2024)

This study revealed that P7C3 inhibited astrocytic senescence via increased Nrf2/Sirt3-mediated mitophagy and suppression of mitoROS, which further protected against DA neuronal loss. These observations provide a prospective theoretical basis for P7C3 in the treatment of age-associated neurodegenerative diseases, such as PD.

Keyphrases

mouse model
dna damage
oxidative stress
endothelial cells
stress induced
signaling pathway
spinal cord
ischemia reperfusion injury
replacement therapy
smoking cessation