Tamoxifen exerts anti-peritoneal fibrosis effects by inhibiting H19-activated VEGFA transcription.

Tingting ZhaoZhengyu SunXueli LaiHongtao LuLulu LiuShuangxi LiJi-Hang YuanZhi-Yong Guo

Published in: Journal of translational medicine (2023)

High glucose-induced MMT of peritoneal mesothelial cells in peritoneal dialysis via activating ESR1. In peritoneal mesothelial cells, ESR1 transcribed the H19 and H19 binds to transcription cofactor p300 to activate the VEGFA. Targeting ESR1/H19/VEGFA pathway provided new hope for patients undergoing peritoneal dialysis.

Keyphrases

peritoneal dialysis
high glucose
end stage renal disease
endothelial cells
induced apoptosis
estrogen receptor
patients undergoing
cell cycle arrest
signaling pathway
chronic kidney disease
transcription factor
cell death
endoplasmic reticulum stress
cell proliferation
cancer therapy
drug delivery