New compounds from Sarcophyton glaucom -derived Penicillium sp.

Further investigation of the residual bioactive compounds produced by the soft coral Sarcophyton glaucom -derived Penicillium sp. MMA afforded five new compounds assigned as 9-methoxy-penicyrone A ( 1 ), 9-methoxy-penicyrone B ( 2 ), 3-hydroxy-2,2,4-trimethyl-pentyl ester ( 3 ), 3-hydroxy-1-isopropyl-2,2-dimethyl-propyl ester ( 4 ), and 3-isobutyryloxy-2,2,4-trimethyl-pentyl linoleate ( 5 ). Additional six known compounds were isolated: penicyrones A-B ( 6 , 7 ), 4-(2-hydroxy-3-butynoxy)benzoic acid ( 8 ), cyclopenol ( 9 ), aspermytin A ( 10 ), and aurantiomide A ( 11 ). Structures of the new compounds ( 1-5 ) were identified by 1D ( 1 H & 13 C) and 2 D ( 1 H- 1 H COSY, HMBC and NOESY) NMR and HRESI-MS spectroscopic data. Biologically, the antimicrobial activities of the obtained compounds were studied as well.