Proton Craniospinal Irradiation with Immunotherapy in Two Patients with Leptomeningeal Disease from Melanoma.
Ugur T SenerMason James WebbWilliam G BreenBryan J NethNadia N LaackDavid RoutmanPaul D BrownAnita MahajanKelsey FrechetteArkadiusz Z DudekSvetomir N MarkovicMatthew S BlockRobert R McWilliamsAnastasios DimouLisa A KottschadeHeather N MontaneSani H KizilbashJian L CampianPublished in: Journal of immunotherapy and precision oncology (2024)
Adding an ICI to pCSI is feasible for patients with LMD and demonstrates a tolerable toxicity profile. While prospective evaluation is ultimately warranted, pCSI with ICI may confer survival benefits, even after prior ICI.