Disinfection Byproduct Recovery during Extraction and Concentration in Preparation for Chemical Analyses or Toxicity Assays.
Stephanie S LauAlexandria L ForsterSusan D RichardsonWilliam A MitchPublished in: Environmental science & technology (2021)
Over 700 disinfection byproducts (DBPs) have been identified, but they account for only ∼30% of total organic halogen (TOX). Extracting disinfected water is necessary to assess the overall toxicity of both known and unknown DBPs. Commonly used DBP extraction methods include liquid-liquid extraction (LLE) and solid-phase extraction (SPE), which may use either XAD resins or other polymeric sorbents. With few exceptions, DBP recoveries have not been quantified. We compared recoveries by LLE, XAD resins, and a mixture of Phenomenex Sepra SPE sorbents (hereafter SPE) for (semi-)volatile DBPs and nonvolatile model compounds at the 1-L scale. We scaled up the three methods to extract DBPs in 10 L of chlorinated creek waters. For (semi-)volatile DBPs, XAD resulted in lower recoveries than LLE and SPE at both 1- and 10-L scales. At the 10-L scale, recovery of certain trihalomethanes and trihalogenated haloacetic acids by XAD was negligible, while recovery of other (semi-)volatile DBPs extracted by XAD (<30%) was lower than by SPE or LLE (30-60%). TOX recovery at the 10-L scale was generally similar by the three extraction methods. The low TOX recovery (<30%) indicates that the toxicity assessed by bioassays predominantly reflects the contribution of the nonvolatile, hydrophobic fraction of DBPs.
Keyphrases
- solid phase extraction
- gas chromatography
- molecularly imprinted
- high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- ms ms
- tandem mass spectrometry
- gas chromatography mass spectrometry
- simultaneous determination
- liquid chromatography
- drinking water
- oxidative stress
- ultra high performance liquid chromatography
- high resolution mass spectrometry
- drug delivery
- high resolution
- high throughput
- water soluble
- anti inflammatory