Lysophosphatidic acid receptor mRNA levels in heart and white adipose tissue are associated with obesity in mice and humans.
Amy BrownIntekhab HossainLester J PerezCarine NziroreraKathleen TozerKenneth D'SouzaPurvi C TrivediChristie AguiarAlexandra M YipJennifer SheaKeith R BruntJean-Francois LegareAnsar HassanThomas PulinilkunnilPetra C KienesbergerPublished in: PloS one (2017)
LPA1-6 were expressed in myocardium and white adipose tissue from mice and humans, except for LPA3, which was undetectable in murine adipocytes and human adipose tissue. Obesity was associated with increased LPA4, LPA5 and/or LPA6 levels in mice ventricles and cardiomyocytes, HL-1 cells exposed to high palmitate, and human atrial tissue. LPA4 and LPA5 mRNA levels in human atrial tissue correlated with measures of obesity. LPA5 mRNA levels were increased in HFHS-fed mice and insulin resistant adipocytes, yet were reduced in adipose tissue from obese patients. LPA4, LPA5, and LPA6 mRNA levels in human adipose tissue were negatively associated with measures of obesity and cardiac surgery outcomes. This study suggests that obesity leads to marked changes in LPA receptor expression in the murine and human heart and white adipose tissue that may alter LPA receptor signaling during obesity.
Keyphrases
- adipose tissue
- insulin resistance
- high fat diet induced
- endothelial cells
- type diabetes
- metabolic syndrome
- high fat diet
- weight loss
- induced pluripotent stem cells
- weight gain
- skeletal muscle
- cardiac surgery
- atrial fibrillation
- binding protein
- acute kidney injury
- oxidative stress
- glycemic control
- left ventricular
- endoplasmic reticulum stress
- high glucose
- left atrial