Influence of pharmacogenetic polymorphisms and demographic variables on metformin pharmacokinetics in an admixed Brazilian cohort.
Ana Beatriz SantoroMariana Rodrigues BottonClaudio José StruchinerGuilherme Suarez-KurtzPublished in: British journal of clinical pharmacology (2018)
A pharmacogenetic marker in OCT1 (SLC22A1 rs12208357), combined with demographic covariates (age, body surface area and individual proportion of African ancestry) and a food effect explained 29.7% of the variability in metformin AUC0-48h .