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Nature and nurture. Genetic and environmental factors on the relationship between back pain and sleep quality.

Juan Jose Madrid-ValeroAlessandro AndreucciEduvigis CarrilloPaulo H FerreiraJose M Martínez-SelvaJuan R Ordoñana
Published in: European journal of pain (London, England) (2022)
Our results confirm a significant association between both chronic NP and LBP and sleep quality. Such relationship comprises both genetic and environmental factors, with a greater relative weight of the latter. A large part of the individual variance for chronic LBP and chronic NP can be accounted for by a latent common factor of 'back pain'. Genetic influences for LBP and NP were mainly shared. However, environmental influences were common for both problems and specific for each of them in similar magnitudes.
Keyphrases
  • sleep quality
  • depressive symptoms
  • physical activity
  • genome wide
  • copy number
  • mental health
  • body mass index
  • drug induced
  • gene expression
  • risk assessment
  • dna methylation
  • life cycle