Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease.

Min QiaoAnnie J LeeDolly Reyes-DumeyerGiuseppe TostoKelley FaberAlison GoateAlan RentonMichael ChaoBrad BoeveCarlos CruchagaMargaret Pericak-VanceJonathan L HainesRoger RosenbergDebby TsuangRobert A SweetDavid A BennettRobert S WilsonTatiana ForoudRichard MayeuxBadri N Vardarajan

Published in: Annals of clinical and translational neurology (2023)

PRS can be used to estimate penetrance and recurrence risk in familial Alzheimer's disease among carriers and non-carries of APOE-ε4.

Keyphrases

cognitive decline
early onset
mild cognitive impairment
metabolic syndrome
insulin resistance