Effectiveness and safety of ranibizumab 0.5 mg in treatment-naïve patients with diabetic macular edema: Results from the real-world global LUMINOUS study.
Paul MitchellTom G SheidowMichel Eid FarahSajjad MahmoodAngelo M MinnellaNicole EterBora EldemHassan A Al-DhibiWayne MacfaddenSoumil ParikhCornelia Dunger-BaldaufMohamed M MahgoubUrsula Schmidt-Erfurthnull nullPublished in: PloS one (2020)
The LUMINOUS study included patients with DME with more diverse baseline characteristics than those in randomized clinical trials. The 1-year data showed improvement in VA with low number of injections in treatment- naïve patients with DME. Greater VA gains were observed in patients who received ≥5 injections. No new safety findings were identified. LUMINOUS confirms the effectiveness and safety of ranibizumab for the treatment of patients with DME in a real-world clinical practice.