Interactions Between Genome-Wide Genetic Factors and Smoking Influencing Risk of Systemic Lupus Erythematosus.

Jing CuiSoumya RaychaudhuriElizabeth W KarlsonCameron SpeyerSusan MalspeisHongshu GuanJeffrey A SparksHongru NiXinyi LiuEmma F Stevens Jessica N WilliamsEmma E DavenportRachel Knevel Karen H Costenbader

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

The strong additive interaction between an updated SLE genetic risk score and current/recent smoking suggests that smoking may influence specific genes in the pathogenesis of SLE.

Keyphrases

systemic lupus erythematosus
genome wide
disease activity
smoking cessation
dna methylation
copy number
gene expression
rheumatoid arthritis
transcription factor