Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis.

Dakota N JacksonMarina PanopoulosWilliam L NeumannKevin TurnerBrandi L CantarelLuAnn Thompson-SnipesThemistocles DassopoulosLinda A FeaginsRhonda F SouzaJason C MillsRichard S BlumbergK VenuprasadWinston E ThompsonArianne L Theiss

Published in: Gut (2020)

Our results identify Paneth cells as highly susceptible to mitochondrial dysfunction and central to the pathogenesis of ileitis, with translational implications for the subset of Crohn's disease patients exhibiting Paneth cell defects.

Keyphrases

single cell
end stage renal disease
cell therapy
ejection fraction
induced apoptosis
newly diagnosed
chronic kidney disease
peritoneal dialysis
stem cells
patient reported outcomes
oxidative stress