Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization.
Hengshuai ZhangXingyou DongZhenxing YangJiang ZhaoQudong LuJingzhen ZhuLongkun LiShanhong YiJie XuPublished in: Drug design, development and therapy (2022)
Increased CXCR4 in the DRG and SDH contributes to colon inflammation-induced bladder overactivity and hyperalgesia partly via the phosphorylation of spinal ERK. Treatment targeting the CXCR4/ERK pathway might provide a potential new approach for the comorbidity between the digestive system and the urinary system.