Evening Primrose Oil Enhances Tamoxifen's Anticancer Activity against Breast Cancer Cells by Inducing Apoptosis, Inhibiting Angiogenesis, and Arresting the Cell Cycle.

Mohammad M Abd-AlhaseebSarah M MassoudFatma ElsayedGamal Abd El Hay Omran Ahmad Salahuddin

Published in: Molecules (Basel, Switzerland) (2022)

The most significant finding of this study was the confirmation of the anticancer activity of the natural product EPO, which potentiated the activity of the anticancer drug TAM against MCF-7 and MDA-MB-231 BC cell lines through the induction of apoptosis, inhibiting angiogenesis and halting cell proliferation.

Keyphrases

breast cancer cells
cell cycle
cell proliferation
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
endothelial cells
signaling pathway
pi k akt
cell death
vascular endothelial growth factor
wound healing
emergency department
drug induced