The parabrachial to central amygdala circuit is a key mediator of injury-induced pain sensitization.
Jeitzel M Torres-RodriguezTorri D WilsonSudhuman SinghSarah ChaudhryAnisha P AdkeJordan J BeckerJenny L LinSantiago Martinez GonzalezOmar Soler-CedenoYarimar CarrasquilloPublished in: bioRxiv : the preprint server for biology (2023)
electrophysiology and chemogenetic intersectional approaches in rodent models of persistent pain. We found that activation of this pathway contributes to injury-induced hypersensitivity, directly demonstrating a critical function of the PbN→CeA circuit in pain modulation.