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Plectin pulls it together, coupling the cortical actin and intermediate filament cytoskeletons.

Joshua A BroussardKathleen Janee Green
Published in: The Journal of cell biology (2022)
The integration of cytoskeletal/adhesive networks is critical to epithelial mechanobiology. In this issue, Prechova et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202105146) demonstrate that the cytolinker protein plectin is essential for the construction of a cortical cytoskeletal architecture required for epithelial tensional homeostasis.
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