Age- and disease-specific reference values for neurofilament light presented in an online interactive support interface.
Lisa VermuntMarco OtteInge M W VerberkJoep KillesteinAfina W LemstraWiesje M van der FlierYolande A L PijnenburgEverard G B VijverbergFemke H BouwmanGido GravesteijnWilma D J van de BergPhilip ScheltensArgonde C van HartenEline A J WillemseCharlotte E TeunissenPublished in: Annals of clinical and translational neurology (2022)
Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age-specific and disease-specific reference values. We here developed an interactive interface to support interpretation of NfL results in human body fluids. We used NfL values of 1698 individuals without a neurological disorder, aged 19-85 years, and patients with MS and dementias. Percentile regression estimates per diagnosis populate interactive graphs, alongside NfL background information (available on: https://mybiomarkers.shinyapps.io/Neurofilament). This accessible interface provides reference for interpretation of the individual patient results for clinicians. It showcases an adaptable method to support interpretation of age-dependent biomarkers in neurology.