Low Inherent Sensitivity to the Intoxicating Effects of Ethanol in Rhesus Monkeys with Low CSF Concentrations of the Serotonin Metabolite 5-Hydroxyindoleacetic Acid.
Elizabeth K WoodRyno KrugerAngus BennionBradley M CookeStephen LindellMelanie SchwandtDavid GoldmanChristina S BarrStephen J SuomiJames Dee HigleyPublished in: Alcoholism, clinical and experimental research (2018)
Our study shows that, in monkeys exposed to alcohol for the first time, objective measures of intoxication are associated with subjective ratings for intoxication, and both were associated with CSF 5-HIAA concentrations. Our data confirm and extend the finding that low CNS serotonin functioning is predictive of intrinsic low sensitivity to the intoxicating effects of EtOH.