Clinical and Neuropathological Features Associated With Loss of RAB39B.

Yujing GaoVerónica Martínez-CerdeñoKirk J HoganCatriona A McLeanPaul J Lockhart

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

T168K RAB39B is unstable in vivo and associated with dopaminergic neuron loss and Lewy pathology. Dysregulation of RAB39B in the prefrontal cortex and substantia nigra of individuals with idiopathic PD potentially implicates the protein more broadly in the pathological mechanisms underlying PD and related Lewy body disorders. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

prefrontal cortex
parkinson disease
amino acid
small molecule
drug induced