Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma.
Juan BayoEsteban J FioreLuciana María DominguezMaría Jose CanteroMatias S CiarlantiniMariana MalviciniCatalina AtorrasagastiMariana Gabriela GarciaMario RossiClaudio N CavasottoElisabeth MartinezJulieta CominGuillermo D MazzoliniPublished in: Gut (2020)
The bioinformatics analysis of the HCC datasets, allows identifying RAC1 as a new therapeutic target for HCC. The targeted inhibition of RAC1 by 1D-142 resulted in a potent antitumoural effect in highly proliferative HCC established in fibrotic livers.