A computational peptide model induces cancer cells' apoptosis by docking Kringle 5 to GRP78.

Published in: BMC molecular and cell biology (2023)

The proposed peptide completely binds to the GRP78 binding site on the Kringle 5, signaling that it might be effective in the apoptosis of cancer cells.

Keyphrases

endoplasmic reticulum stress
oxidative stress
cell cycle arrest
cell death
molecular dynamics
molecular dynamics simulations
cell surface
protein protein