Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study).
Yolandi SnymanAndrew C WhitelawMotlatji R B MalobaAnneke C HesselingMae Newton-FootPublished in: Southern African journal of infectious diseases (2021)
Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in South Africa. However, information on carriage of these bacteria in communities is limited. This study investigated gastrointestinal carriage of colistin-resistant Escherichia coli and Klebsiella spp. and mcr genes in children from communities in Cape Town. Colistin-resistant E. coli was isolated from two participants (4%, 2/50), and mcr-1-mcr-9 genes were not detected. Gastrointestinal carriage of colistin-resistant Enterobacterales was rare; however, continuous extensive surveillance is necessary to determine the extent of carriage and its contribution to resistance observed in clinical settings.
Keyphrases
- escherichia coli
- multidrug resistant
- south africa
- klebsiella pneumoniae
- acinetobacter baumannii
- gram negative
- drug resistant
- hiv positive
- pseudomonas aeruginosa
- public health
- biofilm formation
- genome wide
- clinical trial
- mycobacterium tuberculosis
- study protocol
- mesenchymal stem cells
- hepatitis c virus
- adverse drug
- high resolution
- genome wide identification
- mass spectrometry