The effect of genetically modified platelet-derived growth factor-BB over-expressing mesenchymal stromal cells during core decompression for steroid-associated osteonecrosis of the femoral head in rabbits.

Roberto Alfonso GuzmanMasahiro MaruyamaSeyedsina MoeinzadehElaine LuiNing ZhangHunter W StoraciKaysie TamElijah Ejun HuangTakeshi UtsunomiyaClaire RheeQi GaoZhenyu YaoYunzhi Peter YangStuart B Goodman

Published in: Stem cell research & therapy (2021)

The use of PGK-PDGF-BB-MSCs as an adjunctive treatment with CD may reduce progression of osteonecrosis and enhance bone regeneration and angiogenesis in the treatment of early-stage ONFH.

Keyphrases

growth factor
early stage
bone regeneration
bone marrow
mesenchymal stem cells
minimally invasive
vascular endothelial growth factor
recombinant human
neoadjuvant chemotherapy
sentinel lymph node
smooth muscle
smoking cessation