Non-invasive intradermal imaging of cystine crystals in cystinosis.

Marya BengaliSpencer GoodmanXiaoying SunMagdalene A DohilRanjan DohilRobert NewburyTatiana LobryLaura HernandezCorinne AntignacSonia JainStephanie Cherqui

Published in: PloS one (2021)

This study used non-invasive RCM imaging to develop an intradermal cystine crystal quantification method. Results showed that cystinosis patients had increased nCCV compared to healthy controls. Level of patient nCCV correlated with several clinical outcomes suggesting nCCV may be used as a potential new biomarker for cystinosis to monitor long-term disease control and medication compliance.

Keyphrases

high resolution
end stage renal disease
newly diagnosed
ejection fraction
healthcare
prognostic factors
peritoneal dialysis
case report
emergency department
patient reported outcomes
room temperature
risk assessment
fluorescence imaging
adverse drug
drug induced