LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study.

Tatsuya UenoMegumi SasakiHaruo NishijimaYukihisa FunamizuTomoya KonRie HagaAkira AraiChieko SuzukiJin-Ichi NunomuraMasayuki BabaMasahiko Tomiyama

Published in: Parkinson's disease (2017)

The efficacy of LSVT-BIG for advanced Parkinson's disease (PD) patients with wearing off remains to be determined. Therefore, we evaluated whether LSVT-BIG improves motor disability in eight PD patients with wearing off. Unified Parkinson's Disease Rating Scale (UPDRS) scores, daily off time, and mobility assessments were evaluated during the "on" time before and after the LSVT-BIG course. LSVT-BIG significantly improved UPDRS III scores at 4 weeks and UPDRS II scores in the "off" state at 12 weeks, with no changes in the other measures. The findings suggest that LSVT-BIG may be an effective therapy for advanced PD patients with wearing off.

Keyphrases

big data
open label
artificial intelligence
machine learning
clinical trial
multiple sclerosis
gestational age
physical activity
deep learning
phase ii study