Harnessing Plant Flavonoids to Fight Pancreatic Cancer.
Chen Gu NiuJing ZhangPatrick I OkoloPublished in: Current nutrition reports (2024)
This review found that the plant flavonoids with anti-pancreatic cancer activity mainly include chalcones, dihydrochalcones, flavanols, flavanones, flavones, isoflavonoids, flavonols, isoflavones, and flavanonols. Most of these flavonoids have anti-proliferative, pro-apoptotic, cell cycle arrest, anti-angiogenic, anti-inflammatory, anti-epithelial-mesenchymal transition, and anti-metastatic properties. Some flavonoids can also regulate autophagy, immune and glucose uptake in the context of pancreatic cancer. Several molecules and signaling pathways are associated with the pharmacological activities of plant flavonoids, including AMP-activated protein kinase, mitogen-activated protein kinases, phosphatidylinositol-3-kinase/protein kinase B, nuclear factor-κB, signal transducer, and activator of transcription 3, Smad3, epidermal growth factor receptor, and vascular endothelial growth factor. This review provides strong evidence that plant flavonoids have potential against pancreatic carcinogenesis in experimental animals through various pharmacological mechanisms. They are a promising resource for use as adjuvant anti-cancer therapy. However, randomized controlled clinical trials with those flavonoids are needed.
Keyphrases
- protein kinase
- epithelial mesenchymal transition
- nuclear factor
- epidermal growth factor receptor
- cell death
- vascular endothelial growth factor
- clinical trial
- anti inflammatory
- signaling pathway
- cancer therapy
- tyrosine kinase
- squamous cell carcinoma
- drug delivery
- small cell lung cancer
- early stage
- transforming growth factor
- pi k akt
- machine learning
- blood pressure
- endothelial cells
- adipose tissue
- big data
- phase ii
- human health
- study protocol