The beneficial effect of sleep on behavioral health problems in youth is disrupted by prenatal cannabis exposure: A causal random forest analysis of Adolescent Brain Cognitive Development data.
Philip A SpechlerRoman M GutierrezSusan F TapertWesley K ThompsonMartin P PaulusPublished in: Child development (2023)
Studies suggest prenatal cannabis exposure is associated with mood/behavioral problems in children. However, it is unclear if targeting modifiable domains like sleep behaviors would improve outcomes in exposed youth. Using a causal inference framework, the effect of changing sleep-hours on changing internalizing/externalizing problems in children was examined using the Adolescent Brain Cognitive Development™ study baseline (ages 9-10; collected during 2016-2018) and year-1 follow-up data (N = 9825; 4663 female; 5196 white). Average treatment effects (ATE) indicated that more sleep predicted less internalizing (ATE = -.34, SE = .08, p < .001) and externalizing (ATE = -.29, SE = .07, p < .001) problems over time. However, prenatal cannabis exposure moderated the ATE on internalizing (conditional-ATE = .91, SE = .39, p = .019), whereby participants with exposure (n = 605) did not show any effect of changing sleep-hours on mood (B = .09, SE = .24).
Keyphrases
- mental health
- sleep quality
- young adults
- physical activity
- pregnant women
- resting state
- healthcare
- bipolar disorder
- depressive symptoms
- white matter
- electronic health record
- functional connectivity
- climate change
- single cell
- multiple sclerosis
- adipose tissue
- big data
- cerebral ischemia
- risk assessment
- insulin resistance
- data analysis
- weight loss
- combination therapy