Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans.

Jiaxi SongQicheng NiJiajun SunJing XieJianmin LiuGuang NingWei-Qing Wang Qidi Wang

Published in: The Journal of clinical endocrinology and metabolism (2022)

Our finding highlights that the failure to establish proper adaptive UPR in senescent human beta cells shifts their differentiated states, possibly representing a crucial step in the pathogenesis of age-related beta cell failure.

Keyphrases

single cell
cell therapy
endothelial cells
cell cycle arrest
endoplasmic reticulum stress
cell death
signaling pathway
endoplasmic reticulum
pi k akt