Calcium-dependent cytosolic phospholipase A 2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
Shaowei WangBoyang LiVictoria SolomonAlfred FontehStanley I RapoportDavid A BennettZoe ArvanitakisHelena C ChuiPatrick M SullivanHussein N YassinePublished in: Molecular neurodegeneration (2022)
Our findings implicate greater activation of cPLA2 signaling system with APOE4, which could represent a potential drug target for mitigating the increased neuroinflammation with APOE4 and AD.
Keyphrases
- cognitive decline
- high fat diet
- oxidative stress
- traumatic brain injury
- lipopolysaccharide induced
- lps induced
- cognitive impairment
- mild cognitive impairment
- cerebral ischemia
- inflammatory response
- adipose tissue
- ischemia reperfusion injury
- emergency department
- insulin resistance
- induced apoptosis
- electronic health record