Association between new plasma inflammatory markers and risk of colorectal neoplasms in individuals over 50 years old.

Recently, several studies have explored inflammatory biomarkers associated with colorectal neoplasms in human plasma and investigated the prognostic value of systemic cytokine profiles and inflammatory markers in colorectal cancer. However, little is known about inflammatory biomarkers in colorectal adenoma and early cancer. We compared the level of 38 inflammatory markers in the plasma of 112 adenoma patients, 72 Tis`T1 staging of colorectal carcinoma patients, 34 T2-T4 staging of colorectal carcinoma patients and 53 normal subjects. In summary, we found that eight inflammatory biomarkers (Eotaxin, GCSF, IL-4, IL-5, IL-17E, MCP-1, TNF-alpha, VEGF-A) have higher plasma concentrations in colorectal adenoma and cancer patients compared to normal participants over 50 years old and may have the prognostic value for colorectal adenoma and early -stage carcinoma.