Calcium acts as a central player in melatonin antitumor activity in sarcoma cells.

Ana M Sánchez-Sánchez María Turos-Cabal Noelia Puente-Moncada Federico Herrera Carmen Rodríguez Vanesa Martin

Published in: Cellular oncology (Dordrecht) (2022)

Our data indicate that regulation of calcium homeostasis is a key factor in the inhibition of cell proliferation and migration by melatonin. This effect should be taken into consideration in combined therapies with traditional or new antitumor compounds, since it may circumvent therapy resistance.

Keyphrases

induced apoptosis
cell cycle arrest
cell therapy
single cell
electronic health record
big data
endoplasmic reticulum stress
oxidative stress
stem cells
mesenchymal stem cells
deep learning
smoking cessation