Serum apoptotic marker M30 is positively correlated with early diastolic dysfunction in adolescent obesity.
Ming-Chun YangHsien-Kuan LiuYu-Tsun SuChing-Chung TsaiJiunn-Ren WuPublished in: PloS one (2019)
Diastolic dysfunction was the main change in adolescent obesity. Insulin resistance, apoptotic marker M30, hs-CRP, and IL-6 were all elevated in adolescents with obesity. Only M30 was related to indices of left ventricular diastolic dysfunction among adolescents with obesity, rather than inflammation or insulin resistance.
Keyphrases
- insulin resistance
- left ventricular
- high fat diet induced
- metabolic syndrome
- adipose tissue
- type diabetes
- high fat diet
- young adults
- skeletal muscle
- oxidative stress
- weight loss
- polycystic ovary syndrome
- blood pressure
- weight gain
- cell death
- mental health
- cardiac resynchronization therapy
- heart failure
- hypertrophic cardiomyopathy
- acute myocardial infarction
- ejection fraction
- mitral valve
- glycemic control
- aortic stenosis
- childhood cancer