In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain.
Zac ChattertonBrigham J HartleyMan-Ho SeokNatalia MendelevSean ChenMaria MilekicGorazd RosoklijaAleksandar StankovIskra Trencevsja-IvanovskaKristen BrennandYongchao GeAndrew J DworkFatemeh HaghighiPublished in: Epigenetics & chromatin (2017)
We found evidence that intrauterine smoking exposure alters the developmental patterning of DNA methylation and gene expression and is associated with reduced mature neuronal content, effects that are likely driven by nicotine.
Keyphrases
- dna methylation
- gene expression
- smoking cessation
- cerebral ischemia
- genome wide
- white matter
- resting state
- birth weight
- subarachnoid hemorrhage
- copy number
- brain injury
- pregnancy outcomes
- multiple sclerosis
- functional connectivity
- blood brain barrier
- pregnant women
- body mass index
- gestational age
- weight gain
- cell fate