Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury.

Yang JiaoTi ZhangChengmi ZhangHaiying JiXingyu TongRan XiaWei WangZhengliang MaXueyin Shi

Published in: Critical care (London, England) (2021)

The present study demonstrated that exosomal miR-30d-5p from PMNs contributed to sepsis-related ALI by inducing M1 macrophage polarization and priming macrophage pyroptosis through activating NF-κB signaling. These findings suggest a novel mechanism of PMN-Mϕ interaction in sepsis-related ALI, which may provide new therapeutic strategies in sepsis patients.

Keyphrases

acute kidney injury
septic shock
intensive care unit
cell proliferation
long non coding rna
end stage renal disease
signaling pathway
lps induced
adipose tissue
chronic kidney disease
ejection fraction
oxidative stress
nlrp inflammasome
prognostic factors
immune response
inflammatory response
nuclear factor