Fetal adverse effects following NSAID or metamizole exposure in the 2nd and 3rd trimester: an evaluation of the German Embryotox cohort.

Katarina DatheJohanna FrankStephanie PadbergStefanie HultzschEvelin BeckChristof Schaefer

Published in: BMC pregnancy and childbirth (2022)

NSAID use in the 2nd trimester limited to a few days does not appear to pose a relevant risk. Use for longer periods in the advanced 2nd trimester, however, may cause oligohydramnios and ductus arteriosus constriction similar to effects observed after 3rd trimester use.

Keyphrases

preterm birth
gestational age
pregnancy outcomes
neuropathic pain
pregnant women
spinal cord injury